Transferring Fresh or Frozen Embryos

The Basics of Fresh and Frozen Transfers

Fresh vs Frozen

After a woman has her eggs retrieved, there are typically two options when it comes to the timing of a transfer. The first is a “fresh” transfer, whereby the best embryo(s) are transferred into the uterus only three to five days after the retrieval. Any remaining embryos are frozen for a future transfer, if needed.

Alternatively, all the embryos could be frozen immediately, including the best embryos, to be thawed for a transfer at a later date.

In many cases it will be clear before the cycle even starts that some women will need to do a frozen transfer (for example women who have PCOS or those who want to do PGT-A testing). But in other cases that will only be revealed right before the retrieval (like when a women has high progesterone at the time of retrieval).

Below we summarizes the trade-offs for both approaches.

Fresh Frozen Tradeoffs

Window of Receptivity

As you may recall from other lessons and chapters, nearly all IVF cycles involve stimulating the ovaries to retrieve a high number of eggs. A result of creating so many eggs is that estrogen and progesterone levels can rise 10 times higher than their normal peak levels. The uterus takes note of such a rise and hurries to prepare itself to receive an embryo. Therein lies a problem. That’s because the uterus is only “receptive” to an embryo implanting for a short time, and when it rushes to prepare itself in reaction to the hormonal surge, this “window of receptivity” can be moved earlier.

As a result, in a fresh cycle, by the time an embryo is mature and ready for transfer, the uterus is less likely to be “receptive” and the odds the embryo implants are lower. Conversely, in a frozen cycle, the doctors wait for a woman’s hormonal balance to restore and can transfer the embryo on a later date, at a moment when her uterus is most receptive.

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IVF - In Vitro Fertilization

IVF is complicated and, while we wish we could say that it's possible to absorb all the details during the 5 - 30 minute visits with your doctor, that's really not the case. This comprehensive guide to IVF boils down every major issue you'll encounter -- a high level overview of the IVF process, a deeper dive into the IVF process, IVF success rates and how they differ depending on diagnosis and age, the medication protocols that can be used during IVF, the choice of inseminating eggs either using ICSI fertilization or conventional insemination, the pros and cons of growing embryos to Day 3 cleavage stage or Day 5 blastocyst stage, the decisions around genetic screening of embryos, deciding which embryo to transfer, deciding how many embryos to transfer at once, the ways the IVF laboratory can impact your odds of success and the things you need to know up front to avoid going to the wrong lab for you, the risks of IVF, and the costs of IVF. We're always sure to provide details about how data might be different depending on different unique types of patients -- because in the world of fertility, it's really not one-size-fits-all. We truly believe this guide is the foundation every fertility patient should start with when they're navigating the world of treatments.

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